The Substance Abuse and Mental Health Services Administration provides funding through the Center for Substance Abuse Treatment.

Texas Department of State Health Services administers the cooperative agreement grant .

Harris County Hospital District operates InSight at hospitals and clinics, providing screening, brief intervention, referral, and primary care services as a part of routine medical care.

The Council on Alcohol and Drugs Houston provides outpatient Brief Treatment (a series of individualized counseling sessions), referral to outpatient and inpatient treatment services through a unique arrangement with DSHS, and manages patient follow-up.

University of Texas Health Science Center-Houston provides training, coaching, and provider support for InSight staff.

Baylor College of Medicine provides medical leadership, generalist training and provider support, and content expertise.

University of Texas at Austin Addiction Research Institute provides program evaluation and data management.